Ebola virus disease is difficult to diagnose being that its symptoms resemble those of other diseases such as Typhoid, Malaria, and Meningitis. Tests used for diagnosis are antigen-capture detection tests, electron microscopy, and basic blood tests. Antigen-capture detection tests use antibodies and color change to identify substances, in this case the Ebola virus. Electron microscopy uses a microscope that has high magnification and resolution by using electrons to create an image of the specimen. This procedure makes it easier to identify the virus.

There are no antivirus medications for the virus, however, supportive hospital care can treat the disease. Symptoms and complications are treated as they appear in the patient and basic interventions may significantly improve the chances of survival. Such treatments include providing intravenous fluids to balance electrolytes, maintaining oxygen status and blood pressure, replacing blood that is lost, and treating other infections as they appear. Recovery from Ebola virus disease is highly dependent on good supportive care and the patient's immune response. After recovery, however, the virus may be found in body fluids, such as semen, because it can take up to 3 to 9 months to leave the body's systems.